Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery

Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery 1st Edition
Author: Christopher T. Walsh (Author)
Get this book Contact Email: girro@qq.com
Publisher: Royal Society of Chemistry; 1st edition (October 1, 2018)
Language: English
Hardcover: 785 pages
ISBN-10: 1788010760
ISBN-13: 9781788010764
Book Description
About this book
Authored by leading experts in the enzymology of natural product biosynthesis, this textbook provides a thorough description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.

Although some 500-600,000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism.

This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, to pharmacognocists and chemical ecologists, to bioengineers and synthetic biologists.

Book content
Major Classes of Natural Product Scaffolds and Enzymatic Biosynthetic Machinery
Polyketide Natural Products
Peptide Derived Natural Products
Isoprenoids/Terpenes
Alkaloids
Purine- and Pyrimidine-derived Natural Products
Phenylpropanoid Natural Product Biosynthesis
Indole Terpenes: Alkaloids II
Carbon-based Radicals in C-C Bond Formations in Natural Products. A. Oxygenases B. Oxygen-dependent Halogenases
S-Adenosyl Methionine: One Electron and Two Electron Reaction Manifolds in Biosyntheses
Natural Product Oligosaccharides and Glycosides
Natural Products Isolation and Characterization: Gene Independent Approaches
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