Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling: Science and Applications

ByMicaela Reddy, R. S. Yang, Melvin E. Andersen, Harvey J. Clewell, III

Publisher: Wiley-Interscience
Pages: 420
Source: girro@qq.com
Publication Date: 2005-06-23
ISBN-10: 0471478148
ISBN-13: 9780471478140
Binding: Girro

A definitive, single source of information on PBPK modeling

Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.

This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for:

* Halogenated Alkanes

* Halogenated Alkenes

* Alkene and Aromatic Compounds

* Reactive Vapors in the Nasal Cavity

* Alkanes, Oxyhydrocarbons, and Related Compounds

* Pesticides and Persistent Organic Pollutants

* Dioxin and Related Compounds

* Metals and Inorganic Compounds

* Drugs

* Antineoplastic Agents

* Perinatal Transfer

* Mixtures

* Dermal Exposure Models

In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.

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"A definitive, single source of information on PBPK modeling

Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.

This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for:

Halogenated Alkanes
Halogenated Alkenes
Alkene and Aromatic Compounds
Reactive Vapors in the Nasal Cavity
Alkanes, Oxyhydrocarbons, and Related Compounds
Pesticides and Persistent Organic Pollutants
Dioxin and Related Compounds
Metals and Inorganic Compounds
Drugs
Antineoplastic Agents
Perinatal Transfer
Mixtures
Dermal Exposure Models

In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology,Physiologically-Based Pharmacokinetic Modelingcompiles information from leaders in the field and discusses future directions for PBPK modeling. "

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